Well-established evidence demonstrates that whole-body activity is essential for the development and repair of the CNS, yet traditional rehabilitation is insufficient to drive neural change. Activity-Based Therapy (ABT) offers high-intensity activation of the nervous system for recovery in early intervention and chronic care. In this course, past clinical assumptions will be compared to recent scientific evidence guiding development of ABT. We will describe various activity-based interventions with case study illustrations and supporting data. Special emphasis will be paid to the benefit of mechano-stimulation and emergent trunk control assessment tools with sufficient sensitivity to measure change in the very young patient.