Chronic loneliness is common and often unrecognized in the cancer setting. It is associated with an increased rate of cancer recurrence and mortality. Recently, loneliness has been associated with cancer-related cognitive impairment, which is a major cancer survivorship concern with increasing attention in recent years. Mechanisms by which loneliness may contribute to cognitive impairment will be reviewed. Results from a cognitive rehabilitation intervention that appears promising to decrease symptoms of both loneliness and cognitive impairment will be presented as well as future opportunities for the rehabilitation community to make an impact for this important clinical problem.