Neurodegenerative Disease (e.g. MS, Parkinson's disease)
Neuroplasticity (includes neuroscience)
Oral Presentation
Erin Foster, PhD, OTD, OTR/L
Assistant Professor
Washington University School of Medicine
St.Louis, Missouri
Aimee Morris, MS
Graduate Student
University of Rochester School of Medicine & Dentistry
St. Louis, Missouri
Jonathan Koller, BS
Senior Neuroimaging Engineer
Washington University School of Medicine
St. Louis, Missouri
Abraham Snyder, MD, PhD
Professor
Washington University School of Medicine
St. Louis, Missouri
Joel Perlmutter, MD
Elliot Stein Professor of Neurology
Washington University School of Medicine
St. Louis, Missouri
Meghan Campbell, PhD
Associate Professor of Neurology and Radiology
Washington University School of Medicine
St. Louis, Missouri
This study investigated the relationships between cognitive brain network integrity measured by resting state functional connectivity magnetic resonance imaging (rs-fcMRI) and everyday prospective and retrospective memory among people with Parkinson disease (PD). Notably, this is the first investigation of neural correlates of prospective memory in PD. We found dissociable relationships between distinct rs-fcMRI cognitive networks and reported everyday prospective and retrospective memory in PD: cingulo-opercular network integrity related to prospective memory, while default mode and frontoparietal netrwork integrity related to retrospective memory. Our reslults indicate that there may be a specific pattern of neurobiological dysfunction associated with everyday memory impairment in PD.
Objective : To investigate relationships between cognitive brain network integrity measured by resting state functional connectivity magnetic resonance imaging (rs-fcMRI) and everyday prospective and retrospective memory among people with Parkinson disease (PD)
Design : Cross-sectional
Setting : Academic medical center
Participants (or Animals, Specimens, Cadavers) : 45 PD with normal cognition (PD-NC), 46 PD with mild cognitive impairment (PD-MCI), and 60 healthy control (HC) participants (M [SD] age = 64.6 [8.5], years education = 15.7 [2.6]; 49% male; 91% white)
Interventions : Not applicable
Main Outcome Measure(s) : The self-report Prospective and Retrospective Memory Questionnaire (PRMQ) measured everyday prospective (ProM) and retrospective (RetM) memory. Rs-fcMRI-derived intranetwork integrity scores for the default mode network (DMN), cingulo-opercular control network (CON), frontoparietal control network (FPN), parietal memory network (PMN) and medial temporal lobe network (MTL) measured cognitive brain network integrity. Intranetwork integrity scores are calculated based on the cross-correlations of each node within the networks.
Results : The PD-MCI group had worse PRMQ ProM and RetM scores than the HC and PD-NC groups (p < 0.001), which were equivalent (p ≥ 0.80).There were no group-related differences in cognitive network integrity (p > 0.05). In PD-MCI, CON correlated with PRMQ ProM (r = -0.34, p = 0.02) while DMN and FPN correlated with RetM (r ≤ -0.29, p ≤ 0.05) such that lower network integrity related to worse reported everyday memory. There were no correlations in PD-NC and HC (r > -0.28, p > 0.06).
Conclusions : Our results show dissociable relationships between distinct rs-fcMRI cognitive networks and reported everyday prospective and retrospective memory and indicate that there may be a specific pattern of neurobiological dysfunction associated with everyday memory impairment in PD-MCI. Notably, this is the first investigation of neural correlates of prospective memory in PD.
