We present evidence from a 1-year longitudinal study, using information from the Stroke Recovery in Underserved Population (SRUP) database, for the psychometrics of Center for Epidemiologic Studies Depression Scale (CES-D) in patients after stroke. This study included a sample of 828 adults, 55 years old and older with a first-time stroke, and admitted to one of eleven inpatient rehabilitation facilities in the United States. Confirmatory factor analyses indicated four-factor structure of the CES-D. Classical test theory and Rasch analyses further supported the reliability and validity of the CES-D. This measure allows investigators and clinicians to better characterize depressive symptoms in patients after stroke.