Rochester, Minnesota – United States
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NAME: Qu, Wenchun
eRA COMMONS USER NAME (agency login):
POSITION TITLE: Associate Professor of Physical Medicine & Rehabilitation and Anesthesiology
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)
INSTITUTION AND LOCATION DEGREE
MM/YYYY FIELD OF STUDY
Second Military Medical University
University of Southern California
Biostatistics and Epidemiology
University of Southern California
University of Pennsylvania
Nassau University Medical Center
6/09 Internal Medicine
Mayo Clinic, Rochester
Mayo Clinic, Rochester Resident
A. PERSONAL STATEMENT
My research interests focus on the application of mesenchymal stem cell (MSC) therapy for painful degenerative spine conditions. By investigating the gene network associated with intervertebral disc and cartilage degeneration, we identified genes associated with disc and cartilage degeneration and are developing therapies with MSCs engineered with induction with relevant bioactive molecules or transduced with target genes with adeno-associated vectors. We are also conducting multiple clinical trials using culture expanded MSCs for the treatment of painful degenerative disc disease as well as lumbar facet arthropathy.
1. Onishi K, Jones DL, Riester SM, Lewallen EA, Lewallen DG, Sellon JL, Dietz AB, Qu W, van Wijnen AJ, Smith J. Human Adipose-Derived Mesenchymal Stromal/Stem Cells Remain Viable and Metabolically Active Following Needle Passage. PM R. 2016 Jan 27. pii: S1934-1482(16)00043-5.
2. Cameron, T.L., Belluoccio, D., Farlie, P.G., Brachvogel, B., and Bate- man, J.F. (2009). Global comparative transcriptome analysis of cartilage formation in vivo. BMC Dev. Biol. 9, 20.
3. Wang Z, Terzic CM, Smith J, Mauck WD, Shelerud RA, Maus TP, Yang TH, Murad MH, Gou S, Terry MJ, Dauffenbach JP, Pingree MJ, Eldrige JS, Mohammed K, Benkhadra K, van Wijnen AJ, Qu W. Efficacy of Intervertebral Disc Regeneration with Stem Cells - A systematic review and meta-analysis of animal controlled trials. Gene. 2015 Jun 10;564(1):1-8
B. POSITIONS AND HONORS
Positions and Employment
1996 - 1997 Attending Orthopedist – Spine Service, Orthopedic Surgery, 309 Hospital, Beijing, China
2002 - 2006 Statistician, Children's Oncology Group, Arcadia, CA
2006 - 2007 Adjunct Instructor, Department of Occupational Science and Therapy, University of Southern California, Los Angeles, CA
2011 - 2018 Assistant Professor of Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN
2018 – current Associate Professor of PM&R, Associate Professor of Anesthesiology, Mayo Clinic
2013 - 2016 Senior Associate Consultant, PM&R, Pain Medicine, Mayo Clinic
2016 - Consultant, PM&R, Pain Medicine, Mayo Clinic
Other Experience and Professional Memberships
Editorial Advisory Boards
2016-present Editorial Board member, Journal of American Academy of Regenerative Medicine
2008-present Member, American Academy of Physical Medicine and Rehabilitation
2012-present Member, American Academy of Pain Medicine
2013-present Member, Spine Intervention Society
2016-present Member, American Academy of Regenerative Medicine
2012 Mayo Clinic Scholar Award
2013 Best Basic Science Abstract Award - Spine Intervention Society, Hinsdale, Illinois
2014 Best Scientific Poster - American Academy of Pain Medicine, Chicago, Illinois
2016 Best of Meeting Award - American Society of Regional Anesthesia and Pain Medicine, Pittsburgh, PA
2016 Transform the Practice Initiative Award - Mayo Clinic, Rochester, MN
2017 Best Original Research Award - Foundation for Physical Medicine and Rehabilitation, Denver, CO
2017 Best of Meeting Award - American Society of Regional Anesthesia and Pain Medicine, Orlando, FL
2017 Transform the Practice Initiative Award - Mayo Clinic, Rochester, Minnesota
C. CONTRIBUTION TO SCIENCE
Establishing safety of cultural expanded adipose-derived stem cell (AMSC) therapy for knee arthritis. My group has conducted transplantation of AMSC to rabbit knee and established safety profiles important for designing clinical trials for AMSC therapy for knee osteoarthritis.
a. Scott M. Riester, Janet Denbeigh, Yang Lin, Dakota L. Jones, Hai Nie, Chris Paradise, Eric A. Lewallen, Darcie J. Radel, Amel Dudakovic, Emily Camilleri, Wenchun Qu, Aaron Krych, Matthew A. Frick, Hee-Jeong Im, Allan B. Dietz, Jay Smith, Andre J. van Wijnen. Safety studies for use of adipose tissue-derived mesenchymal stromal/stem cells in a rabbit model for osteoarthritis to support Phase I human trials. PLoS One. Submitted
b. Onishi K, Jones DL, Riester SM, Lewallen EA, Lewallen DG, Sellon JL, Dietz AB, Qu W, van Wijnen AJ, Smith J. Human Adipose-Derived Mesenchymal Stromal/Stem Cells Remain Viable and Metabolically Active Following Needle Passage. PM R. 2016 Jan 27. pii: S1934-1482(16)00043-5.
Establish efficacy of stem cell therapy for intervertebral disc degeneration in animal models.
My group has conducted meta-analysis which concluded the efficacy of animal trials in stem cell therapy for intervertebral disc degeneration.
a. Wang Z, Terzic CM, Smith J, Mauck WD, Shelerud RA, Maus TP, Yang TH, Murad MH, Gou S, Terry MJ, Dauffenbach JP, Pingree MJ, Eldrige JS, Mohammed K, Benkhadra K, van Wijnen AJ, Qu W. Efficacy of Intervertebral Disc Regeneration with Stem Cells - A systematic review and meta-analysis of animal controlled trials. Gene. 2015 Jun 10;564(1):1-8
D. RESEARCH SUPPORT
On-going Research Support
Transform the Practice Initiative Award 1/1/2017 – 12/31/2020
Title: A Phase I Dose-escalation Study Evaluating the Safety and Preliminary Efficacy of Adipose-derived Mesenchymal Stem Cells in Subjects with Painful Degenerative Disc Disease
The goal of this study is to determine the safety, feasibility, and efficacy of treatment of discogenic pain with mesenchymal stem cells.
Transform the Practice Initiative Award 1/1/2018 – 12/31/2020
Title: CELLTOP: Phase I/II Clinical Trial of Autologous Adipose Derived Mesenchymal Stem Cells in the Treatment of Paralysis due to Traumatic Spinal Cord Injury
The goal of this study is to determine the safety, feasibility, and efficacy of treatment of spinal cord injury with mesenchymal stem cells.
Gerstner Spine Initiative Award 8/1/2019 – 7/31/2022
Title: CellKine: Phase I Study Evaluating the Safety an Feasibility of Autologous, Culture-expanded. Adipose-Derived Mesenchymal Stem Cells in Subjects with Painful Lumbar Facet Arthropathy.
Thursday, November 7
3:55 PM – 4:30 PM