Baylor College of Medicine
OMB No. 0925-0001 and 0925-0002 (Rev. 09/17 Approved Through 03/31/2020)
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FIVE PAGES.
NAME: LEVIN, HARVEY
eRA COMMONS USER NAME (credential, e.g., agency login): HARVLEV
POSITION TITLE: Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION DEGREE
FIELD OF STUDY
City College of the City University of NY
University of Iowa, Iowa City, IA
University of Iowa, Iowa City, IA
University of Iowa Hospitals, Iowa City, IA
Illinois Masonic Medical Center, Chicago, IL B.A.
A. Personal Statement
I am a neuropsychologist with the training and experience to serve as a partnering principal investigator on this project concerning the effects of sports related concussion and other causes of traumatic brain injury (TBI) on neurovascular coupling and neurometabolic coupling using high spatiotemporal arterial spin labeling MRI, and computational modeling to quantify oxygen metabolism. The goal of this project is to develop a novel diagnostic and prognostic biomarker for TBI, including sports related concussion. I have directed productive NIH and other federally funded projects on sports concussion, non-sports mild TBI, and more severe TBI which used multimodality brain imaging and neuropsychological outcome measures. These multidisciplinary projects challenged the prevailing clinical practice and had a substantial impact on the direction of research.
1. Newsome MR, Scheibel RS, Chu Z, Hunter JV, Li X, Wilde EA, Lu H, Wang ZJ, Lin X, Steinberg JL, Vasquez AC, Cook L, Levin HS. The relationship of resting cerebral blood flow and brain activation during a social cognition task in adolescents with chronic moderate to severe traumatic brain injury: a preliminary investigation. Int J Dev Neurosci. 2012 May;30(3):255-66. PMID:22120754
2. Newsome M.R., Li X., Lin X, Wilde E.A., Ott S., Biekman B., Hunter J.V., Dash P.K., Taylor B.A., Levin H.S. Functional connectivity is altered in concussed adolescent athletes despite medical clearance to return to play: A preliminary report. Front Neurol. 2016 7 (116), 1-9
3. Ware AL, Wilde EA, Newsome MR, Moretti P, Abildskov T, Vogt GS, McCauley SR, Hanten G, Hunter JV, Chu ZD, Levin HS. A preliminary investigation of corpus callosum subregion white matter vulnerability and relation to chronic outcome in boxers. Brain Imaging Behav. 2018 doi: 10.1007/s11682-018-0018-7. PMID: 30565025
4. Wilde EA, Newsome M, Ott SD, Hunter JV MD, Dash PK, Redell JB, Spruiell M, Diaz M, Chu ZD, Goodrich-Hunsaker NJ, Petrie JA, Li R, Levin H. Persistent Disruption of Brain Connectivity After Sports-Related Concussion in a Female Athlete. J Neurotrauma. 2019 May 23. doi: 10.1089/neu.2019.6377. PMID: 31119974
B. Positions and Honors
1972 Instructor, Department of Psychology, University of Iowa
1974-1979 Assistant Professor, Division of Neurosurgery, Department of Surgery, and Departments of Neurology and Psychiatry, The University of Texas Medical Branch (UTMB), Galveston, TX
1979-1987 Associate Professor, Division of Neurosurgery, Depart of Surgery, UTMB, Galveston, TX
1987-1993 Chela and Jimmy Storm Distinguished Professor in Surgical Research, Division of Neurosurgery, Department of Surgery, UTMB, Galveston, TX
1993-1995 Professor, Department of Surgery, Division of Neurosurgery, University of Maryland Medical System, Baltimore, MD
1995-Present Professor, Departments of Physical Medicine and Rehabilitation, Neurology, Pediatrics, Neurosurgery, and Psychiatry, Baylor College of Medicine, Houston, TX
1995-2014 Director of Research, Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX
2006-Present Research Scientist, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX
2008-2012 Director, Center of Excellence on Traumatic Brain Injury, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX
2010-Present Invited Lecturer, University of Athens Neuropsychology Graduate Program, Athens, Greece
2004-Present Adjunct Professor, Department of Psychology, Rice University, Houston, TX
Other Experience and Professional Memberships
1974- Member, International Neuropsychological Society
1982- Member, Academy of Aphasia
1992- Member, Memory Disorders Society
1972- Member, American Psychological Association
1989-90 President, International Neuropsychological Society
1990- Member, National Neurotrauma Society
1998-02 Member, Subcommittee on Medical Rehabilitation Research, National Center for Medical
Rehabilitation Research, NICHD
1999- Section Editor, Journal of Neurotrauma
2007-08 Member, Gulf War and Health: Brain Injury in Veterans and Long-Term Health Outcomes, Institute of Medicine
2010-13 Member, Rehabilitation Research and Development Service Merit Review Board
2007-11 Member, Data Safety Monitoring Committee, Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT), National Center for Medical Rehabilitation Research
2009-10 Member, NCMRR/NICHD Data Safety Monitoring Committee for Traumatic Brain Injury Clinical Trials Network
2010-15 Member, Advisory Committee, Progesterone for the Treatment of Traumatic Brain Injury (ProTECT III), NINDS Clinical Trial
2011 Member, Committee on Cognitive Rehabilitation Therapy for Traumatic Brain Injury, Inst. of Med.
2012 Member, Chronic Brain Injury Special Emphasis Panel, Rehabilitation Research and Development, US Department of Veterans Affairs
2013- NICHD Special Emphasis Panel
2014- NINDS Special Emphasis Panels
1984 NINCDS Javits Neuroscience Investigator Award
1985 William F. Caveness Award, National Head Injury Foundation
1988 Texas Psychological Association Award for Outstanding Work in the Traumatic Brain Injury
1990 NINDS Javits Neuroscience Investigator Award
1998 Distinguished Neuropsychologist Award, National Academy of Neuropsychology
2007 Research Award, North American Brain Injury Society
2011 Deborah L. Warden Lectureship Award, Defense and Veterans Brain Injury Center
2012 Jennett-Plum Award for Traumatic Brain Injury Research, International Brain Injury Association
2013 Distinguished Career Award, International Neuropsychological Society
2015 Research Faculty of the Year, Baylor College of Medicine
2018 American Congress of Rehabilitation Medicine Gold Key Research Award, October, 2018
B. Contributions to Science
1. I have contributed to prospective studies of TBI by large consortia such as TRACK-TBI and reviews organized by the NINDS.
a. Yue JK, Levin HS, Suen CG, Morrissey MR, Runyon SJ, Winkler EA, Puffer RC, Deng H, Robinson CK, Rick JW, Phelps RRL, Sharma S, Taylor SR, Vassar MJ, Cnossen MC, Lingsma HF, Gardner RC, Temkin NR, Barber J, Dikmen SS, Yuh EL, Mukherjee P, et al. Age and sex-mediated differences in six-month outcomes after mild traumatic
brain injury in young adults: a TRACK-TBI study. Neurol Res. 2019 Jul;41(7):609-623. [citation] PMID: 31007155
b. Nelson LD, Temkin NR, Dikmen S, Barber J, Giacino JT, Yuh E, Levin HS, McCrea MA, Stein MB, Mukherjee P, Okonkwo DO, Diaz-Arrastia R, Manley GT; and the TRACK-TBI Investigators., Adeoye O, Badjatia N, Boase K, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K; et al. Recovery After Mild Traumatic Brain Injury in
Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study. JAMA Neurol. 2019 Jun 3. doi: 10.1001/jamaneurol.2019.1313. [Epub ahead of print] Erratum in: JAMA Neurol. 2019 Oct 21;:. PubMed [citation] PMID: 31157856, PMCID: PMC6547159
c. Stein MB, Jain S, Giacino JT, Levin H, Dikmen S, Nelson LD, Vassar MJ, Okonkwo DO, Diaz-Arrastia R, Robertson CS, Mukherjee P, McCrea M, Mac Donald CL, Yue JK, Yuh E, Sun X, Campbell-Sills L, Temkin N, Manley GT; and the TRACK-TBI Investigators., Adeoye O, Badjatia N, et al. Risk of Posttraumatic Stress Disorder and Major Depression in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study. JAMA Psychiatry. 2019 Mar 1;76(3):249-258. PMID: 30698636
d. Broglio SP, Kontos AP, Levin H, Schneider K, Wilde EA, Cantu RC, Feddermann-Demont N, Fuller GW, Gagnon I, Gioia GA, Giza C, Griesbach GS, Leddy JJ, Lipton ML, Mayer AR, McAllister TW, McCrea M, McKenzie LB, Putukian M, Signoretti S, Suskauer SJ, Tamburro R, et al. National Institute of Neurological Disorders and Stroke and Department of Defense Sport-Related Concussion Common Data Elements Version 1.0 Recommendations. J Neurotrauma. 2018, 35:2776-2783.
2. Our group characterized the acute and long term effects of TBI and the relation to imaging and neurodegeneration. This work has encompassed the long term outcome of a single and repetitive concussion associated with repetitive subconcussive head impacts. In addition, my laboratory investigated cerebral perfusion using arterial spin label MRI.
a. Wu T, Merkley TL, Wilde EA, Barnes A, Li X, Chu ZD, McCauley SR, Hunter JV, Levin HS. A preliminary report of cerebral white matter microstructural changes associated with adolescent sports concussion acutely and subacutely using diffusion tensor imaging. Brain Imaging Behav. 2018 12:962-973. /s11682-017-9752-5.
b. Wilde EA, Hunter JV, Li X, Amador C, Hanten G, Newsome MR, Wu TC, McCauley SR, Vogt GS, Chu ZD, Biekman effects of boxing: Diffusion tensor imaging and cognitive findings. J Neurotrauma. 2016 33 :672-80.
c. Newsome MR, Steinberg JL, Scheibel RS, Troyanskaya M, Chu Z, Hanten G, Lu H, Lane S, Lin X, Hunter JV, Vasquez C, Zientz J, Li X, Wilde EA, Levin HS. Effects of traumatic brain injury on working memory-related brain activation in adolescents. Neuropsychology. 2008 4:419-25.
d. Narayana PA, Yu X, Hasan KM, Wilde EA, Levin HS, Hunter JV, Miller ER, Patel Narayana PA, Yu X, Hasan KM, Wilde EA, Levin HS, Hunter JV, Miller ER, Patel VK, Robertson CS, McCarthy J Multi-modal MRI of mild traumatic brain injury. Neuroimage Clin. 2014 7:87-97.
3. My laboratory conducted research using structural and functional imaging which elucidated the long term effects of TBI on cognition and social cognition.
a. Newsome MR, Durgerian S, Mourany L, Scheibel RS, Lowe MJ, Beall EB, Koenig KA, Parsons M, Troyanskaya M, Reece C, Wilde E, Fischer BL, Jones SE, Agarwal R,Levin HS, Rao SM. Disruption of caudate working memory activation in chronic blast-related traumatic brain injury. NeuroImage: Clinical,8;8:543-553
b. McCauley SR, Wilde EA, Merkley TL, Schnelle KP, Bigler ED, Hunter JV, Chu Z, Vásquez AC, Levin HS. Patterns of cortical thinning in relation to event-based prospective memory performance three months after moderate to severe traumatic brain injury in children. Dev Neuropsychol. 2010 35 :318-32.
c. Newsome MR, Scheibel RS, Hanten G, Chu Z, Steinberg JL, Hunter JV, Lu H, Vasquez AC, Li X, Lin X, Cook L, Levin HS. Brain activation while thinking about the self from another person's perspective after traumatic brain injury in adolescents. Neuropsychology. 2010 ;24(2):139-47.
d. Newsome MR, Mayer AR, Lin X, Troyanskaya M, Jackson GR, Scheibel RS, Walder A, Sathiyaraj A, Wilde EA, Mukhi S, Taylor BA, Levin HS. chronic effects of blast-related mild TBI on subcortical functional connectivity in veterans (2016) Journal of the International Neuropsychological Society, 22 (6), p. 631-42.
D. Research Support
1R43HD09703901 Southern (PI) 8/31/19-9/30/2020
Saliva Biomarkers for Acute mTBI in Children
The goal of this SBIR project is to develop a rapid commercial test for noninvasive diagnostics of mTBI in children. The Phase I research provides proof-of-concept for the core technology: saliva biomarkers with high diagnostic accuracy and specificity for acute pediatric mTBI. This project also evaluates the prognostic utility of the saliva biomarkers for persistent post-concussion symptoms.
Role: Site PI
PT13078 DOD, Manley (PI) 09/1/2014-08/31/2020
TBI Endpoints Development (TED)
The major goals are to evaluate the diagnostic and prognostic usefulness of biofluid and imaging biomarkers and clinical outcome assessments using a meta-database.
HD090817-01A1 Southern (PI) 11/1/18-10/31/20
Rapid Saliva Test for Diagnostics of Neuro-Cognitive Disorder due to TBI
The major goal of this study is to investigate the diagnostic accuracy of biomarkers measured from saliva in adults and adolescents with acute mild TBI; the prognostic usefulness of these biomarkers will also be studied.
Completed Research Support
VA, RRD/CDMRP Walker (PI) NCE 9/30/18-9/29/19
Chronic Effects of Neurotrauma Consortium (CENC).Project 1
The major goal is to longitudinally study post-deployment outcomes in combat exposed veterans who had mild TBI as compared with veterans who were exposed to combat, but did not sustain a TBI.
CDMRP Schneider (PI) 07/01/12-09/29/17
TBI Biological Diagnosis via High Definition Tractography Asymmetry Screening.
Agency: NIH /PI
CDMRP BrainScope Levin/Wilde (Co-PI) 07/01/15 -06/30/17
Objective Brain Function Assessment of mTBI from Initial Injury to Rehabilitation and Treatment Optimization
VA/CDMRP Wilde (PI) NCE 6/30/18–06/29/19
Chronic Effects of Neurotrauma Consortium (CENC) Imaging Core.
The major goal is to oversee the quality assessment of imaging at the study sites for CENC, analyze the imaging data, and disseminate the results.
Thursday, October 22, 2020
3:50 PM – 4:07 PM EST