(P16-017-20) Effectiveness of Coenzyme Q10 Supplementation for Improving Cardiometabolic Outcomes: An Umbrella Review of Meta-Analyses

Objectives: To determine if published meta-analyses support the use of coenzyme Q10 supplementation for improving cardiometabolic function.

Methods: A PubMed search from January 1, 1980 to November 30, 2019 was conducted to find meta-analyses on coenzyme Q10 supplementation that provided quantitative statistical analysis on cardiometabolic outcomes. The following was extracted and entered into an Excel spreadsheet: number of publications included in the meta-analysis, number of total participants, coenzyme Q10 dose, pooled treatment effects for various cardiometabolic clinical endpoints, and tests for heterogeneity and publication bias.

Results: Twenty-two meta-analyses were reviewed which investigated coenzyme Q10’s effects on various cardiometabolic outcomes. Presented here is the ratio of studies showing statistically significant outcomes for the following cardiometabolic functions: 2/3 ejection fraction; 1/1 flow mediated dilation; 0/2 systolic blood pressure; 0/2 diastolic blood pressure; 3/8 lipid profile; 3/6 fasting blood glucose; 2/5 HbA1c; 3/7 C-reactive protein; 5/6 interleukin-6 and 4/5 tumor necrosis factor-α. Significant heterogeneity was observed in the majority (18/23) of these significant findings.

Conclusions: This umbrella review of meta-analyses shows that there is a questionable benefit for recommending coenzyme Q10 supplementation to patients with cardiovascular disease, and the significant heterogeneity observed further undermines this support.

Funding Sources: No funding sources were utilized.